PD-L1

CD274
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	3BIK, 3BIS, 3FN3, 3SBW, 4Z18, 4ZQK, 5C3T, 5J89, 5J8O
識別子
記号	CD274, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, CD274 molecule, Programmed cell death ligand 1, hPD-L1
外部ID	OMIM: 605402 MGI: 1926446 HomoloGene: 8560 GeneCards: CD274
遺伝子の位置 (ヒト)
染色体	9番染色体 (ヒト)
終点	5,470,566 bp
遺伝子の位置 (マウス)
染色体	19番染色体 (マウス)
終点	29,365,495 bp
遺伝子オントロジー
分子機能	• 血漿タンパク結合;
細胞の構成要素	• integral component of membrane; • 膜; • cell surface; • エキソソーム; • external side of plasma membrane; • 細胞内膜系; • 細胞膜; • early endosome membrane; • recycling endosome membrane; • エンドソーム;
生物学的プロセス	• negative regulation of interleukin-10 production; • response to cytokine; • negative regulation of interferon-gamma production; • negative regulation of tumor necrosis factor superfamily cytokine production; • positive regulation of cell migration; • T cell costimulation; • toxin transport; • negative regulation of activated T cell proliferation; • regulation of activated T cell proliferation; • 細胞表面受容体シグナル伝達経路; • negative regulation of T cell proliferation; • regulation of T cell apoptotic process; • 免疫応答; • positive regulation of T cell proliferation; • シグナル伝達; • regulation of activated CD4-positive, alpha-beta T cell apoptotic process; • positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process; • positive regulation of tolerance induction to tumor cell; • negative regulation of CD8-positive, alpha-beta T cell activation; • 免疫系プロセス; • negative regulation of CD4-positive, alpha-beta T cell proliferation; • cellular response to lipopolysaccharide; • adaptive immune response;
	出典:Amigo / QuickGO
オルソログ
	29126
	60533
	ENSG00000120217
	ENSMUSG00000016496
	Q9NZQ7
	Q9EP73
	NM_001314029; NM_001267706; NM_014143
	NM_021893
	NP_001254635; NP_001300958; NP_054862
	NP_068693
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

PD-L1（プログラム細胞死リガンド1, Programmed death-ligand 1 別名:B7-H1）はPD-1のリガンドである免疫チェックポイント・タンパク質。

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120217 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016496 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120217 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016496 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

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